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Häufige Immunphänotypen verschiedener Neoplasien |
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Karzinogene und Manifestationsort
assoziierter Tumoren
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positiv |
negativ |
| Haut
PlattenepithelCa
MerkelzellCa
TalgdrüsenCa
Malignes Melanom |
CK 5/6, 8/18, (10), (13), 14, 15, 17, 19
CK 8/18, 19, 20, Chromogranin,
Synaptophysin, NSE
CK 5/6, 7, 8/18, 19, CEA, AR, (c-erbB2)
S-100, HMB-45, Melan-A, Vimentin
|
CK 7, 20
CK 5/6, 7
panCK, EMA,
Desmoplakin |
| Nasopharynx
undiff. Ca
Meningeom |
CK 8/18, EBV / LMP1
Vimentin, EMA |
CK 7, 20
panCK |
| Tonsille, Kehlkopf
PlattenepithelCa |
CK 5/6, 8/18, (10), (13), 14, 15, 17, 19, (HPV) |
CK 7, 20 |
| Schilddrüse
follikuläres, papilläres Ca
medulläres Ca |
CK 8/18, Thyreoglobulin, TTF-1, Vimentin
CK 8/18, Calcitonin, CEA, Chromogranin,
Synaptophysin, NSE
|
CK 5/6, 7, 20
CK 5/6, 7, 20
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| Lunge
Plattenepithel-Ca
Adeno-Ca
bronchioalveoläres Ca
kleinzelliges Ca |
CK 5/6, 8/18, (10), (13), 14, 15, 17, 19; CD56, (TTF-1)
CK 7, 8/18, 19; CEA, E-Cadherin, TTF-1, Surfactant, (Vimentin),
EMA zytoplasmamtisch
CK 7, 8/18, 19, TTF-1, Surfactant
CK 8/18, (19); CD56, NSE, (Synaptophysin), (Chromogranin
A), (Neurofilament), TTF-1
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CK 7, 20
CK 5/6, 20; (Vimentin)
CK 5/6, 20
CK 5/6, 7, 20
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| Pleura
Mesotheliom |
CK 5/6, 7, 8/18, 14, (17), 19; Vimentin, HBME-1,
EMA membranständig, Calretinin, Thromb-b-modulin
|
CK 20, CEA, CD15
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| Mamma
invasiv duktal
invasiv lobulär |
CK 7, 8/18, 19, ER, PR, (c-erbB2)
CK 7, 8/18, 19, ER, PR, (c-erbB2)
|
CK (5/6), 20
CK (5/6), 20
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| Ösophagus
Plattenepithel-Ca
AdenoCa |
CK 5/6, (10), 14, 15, 17, 8/18, 19
CK (7), 8/18, 19, (20)
|
CK 7, 20
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| Magen
AdenoCa
SiegelringzellCa
neuroendokrine Tu
GIST |
CK (7), 8/18, 19, (20)
CK 7, 8/18, 19, (20), Ca19.9
CK 8/18, 19, Chromogranin, Synaptophysin,
NSE, (Gastrin, Serotonin, andere Hormone)
CD117 /c-Kit, CD34, (Aktin), Vim |
CK 7, 20
panCK
|
| Leber
HCC
CCC |
CK (7), 8/18, (19), OCH1, AFP, (a1AT)
CK 7, 8/18, 19, Ca19.9
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CK 20, EMA
CK 20
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| Gallenwege
AdenoCa
muz. zyst. Tumor |
CK 7, 8/18, 19, (20), Ca19.9
Stroma: ER, PR
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|
| Pankreas
duktales AdenoCa
AzinuszellCa
(neuro)endokrine Tu |
CK 7, 8/18, 19, (20), Ca19.9
CK (7), 8/18, 19, Chymotrypsin, Lipase
CK 8/18, 19, Chromogranin, Synaptophysin,
NSE, Inselzell-Hormone
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CK 20
CK 7, 20
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| Papilla Vateri
duktales AdenoCa
intest. AdenoCa |
CK 7, 8/18, 19, (20), Ca19.9, CEA
CK 8/18, 19, 20, Ca19.9, CEA
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CK 7
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| Dünndarm
AdenoCa |
CK 7, 8/18, 19, (20), CEA
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| Colon, Rektum
AdenoCa
SiegelringzellCa |
CK 8/18, 19, 20, CEA
CK 7, 8/18, 19, (20), Ca19.9
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CK 7
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| Analkanal
Plattenepithel-Ca
Melanom |
CK 5/6, 8/18, (10), 13, (14), 15, 17, 19, 20,
HPV
S-100, HMB-45, Melan-A, Vimentin
|
CK 7
panCK, EMA,
Desmoplakin
|
| Niere
klarzelliges Ca
chromophobes Ca |
CK 7, 8/18, 19, Vimentin
CK 8/18, (19), Hale-Färbung
|
CK 5/6, 20
CK 5/6, 7, 20
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| Nebenniere
NNR-Karzinom
Phäochromozytom |
CK (8/18), Synaptophysin
Vimentin, Chromogranin, Synaptophysin
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panCK |
| Harnblase
UrothelCa |
CK 5/6, CK 7, 8/18, 13, 19, 20, Ca19.9,
Thrombmodulin
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| Prostata
AdenoCa |
CK 8/18, 19, PSA, PSAP, AR |
CK7, CK20
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| Peritoneum
seröses papilläres Ca |
CK 5/6, 7, 8/18, 17, 19, Ca 12-5, Vimentin
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CK 20
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| Ovar, Adenokarzinom
muzinös, endometrioid
serös
Keimstrang-/
Stroma- Tumoren |
CK (7), 8/18, 19, 20
CK 5/6, 7, 8/18, 17, 19
Inhibin, Vimentin |
CK 20
EMA |
| Cervix uteri
Plattenepithel-Ca |
CK 5/6, 8/18, 13, 14, p53, HPV, ER, PR |
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| Corpus uteri
AdenoCa, endometrioid
AdenoCa, serös
Chorionkarzinom
PSTT |
CK 7, 818, 19, 20, ER, PR
CK 5/6, 7, 8/18, 19, 20, p53, Vimentin
CK 8/18, HCG, (hPL), (PlAP), Inhibin, CD146
CK 8/18, hPL, (HCG) |
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| Keimzelltumoren
Seminom, (Dys)germinom
Embryonales Karzinom
Dottersacktumor
Chorionkarzinom |
PlAP, CD117 /c-Kit, Cyclin A
CK 8/18, CD30, (PlAP)
CK 8/18, CD117 /c-Kit, AFP
CK 8/18, HCG, (hPL), Inhibin, CD146 |
panCK
CK 7, 20
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